HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in ADC Online Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huysman, W A Articles by Sauer, P J J Search for Related Content PubMed PubMed Citation Articles by Huysman, W A Articles by Sauer, P J J

Growth and body composition in preterm infants with bronchopulmonary dysplasia

¹ Department of Pediatrics, Division of Neonatology, Sophia Children’s Hospital, Rotterdam, The Netherlands
² Department of Biostatistics and Epidemiology, Erasmus University, 3000 DR Rotterdam
³ Verpleeghuis Drie Maashaven, 3146 CT Maassluis, The Netherlands
⁴ Department of Pediatrics, Beatrix Children’s Hospital/ University Hospital Groningen, 9700 CB Groningen, The Netherlands

Correspondence to:
Correspondence to:
Dr Huysman, Sophia Children’s Hospital/ Erasmus Medical Center Rotterdam, PO Box 2060, 3000 CB Rotterdam, The Netherlands;
huysman{at}alkg.azr.nl

Objective: To compare growth and body composition in preterm infants with bronchopulmonary dysplasia (BPD) with normal healthy term infants during the first year of life.

Design: Twenty nine preterm infants with BPD (mean (SD) gestational age 27.1 (1.6) weeks; birth weight 852 (173) g) were followed prospectively. Anthropometry and body composition determined by total body electrical conductivity were measured and compared with those of healthy term infants at the same post-term age.

Results: In infants with BPD, the mean weight standard deviation scores (SD scores) 6 weeks after term were significantly lower (-1.44 and -2.68, boys and girls respectively) than in healthy term infants of the same age and did not improve during the first year. The mean length SD score was significantly lower in infants with BPD 6 weeks after term than in healthy term infants of the same age, and, although it improved significantly during the first year, the mean length SD score in girls with BPD was significantly below 0 12 months after term. In infants with BPD, the mean free fat mass (FFM) SD score and the mean total body fat (TBF) SD score at 6 weeks post-term age were significantly below 0. The mean FFM SD scores (-1.01 and -2.56, boys and girls respectively) and the mean TBF SD scores (-1.14 and -2.40, boys and girls respectively) 12 months after term were significantly lower than in healthy term infants of the same age.

Conclusions: Preterm infants with BPD have impaired growth, with a deficit in TBF and FFM already 6 weeks after term; FFM and TBF remain low compared with healthy term infants during the first year of life. Nutritional intervention studies in infants with BPD are needed to evaluate if nutrition is the major determinant of growth and body composition or if this pattern of growth in preterm infants with BPD is the result of disturbed endocrine control.

Keywords: preterm; bronchopulmonary dysplasia; growth; body composition

Abbreviations: BPD, bronchopulmonary dysplasia; TOBEC, total body electric conductivity; FFM, fat free mass; TBF, total body fat

This article has been cited by other articles:

				P. J. Sauer Can extrauterine growth approximate intrauterine growth? Should it? Am. J. Clinical Nutrition, February 1, 2007; 85(2): 608S - 613S. [Abstract] [Full Text] [PDF]

				S. J. Carlson Current Nutrition Management of Infants With Chronic Lung Disease Nutr Clin Pract, December 1, 2004; 19(6): 581 - 586. [Abstract] [Full Text] [PDF]