© 2003 Archives of Disease in Childhood Fetal and Neonatal Edition
ORIGINAL ARTICLE
S100 protein content of umbilical cord blood in healthy newborns in relation to mode of delivery
1 Department of Anesthesiology, St Antonius Hospital, Nieuwegein, The Netherlands
2 Department of Gynecology and Obstetrics, St Antonius Hospital
3 Department of Pediatrics, St Antonius Hospital
4 Clinical Laboratory, St Antonius Hospital
5 Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands
Correspondence to:
Correspondence to:
Dr Wirds, PO Box 2500, 3430 EM Nieuwegein, The Netherlands;
jwwirds{at}planet.nl
Background: Early detection and quantification of brain damage in neonatal asphyxia is important. In adults, S100 protein in blood is associated with damage to the central nervous system.
Objective: To determine whether S100 protein can be detected in arterial and venous cord blood of healthy newborns and to relate S100 protein concentrations in cord blood to mode of delivery.
Method: S100 protein levels in umbilical cord blood of 81 healthy infants were determined.
Results: S100 protein was present in arterial (median concentration 1.62 µg/l) and venous (median concentration 1.36 µg/l) cord blood. Levels were significantly higher in vaginal births (median arterial concentration 1.72 µg/l; median venous concentration 1.48 µg/l) than births by caesarean section (1.51 µg/l and 1.26 µg/l respectively).
Conclusion: More research is necessary to determine whether S100 protein is a useful marker in neonatal asphyxia.
Keywords: S100 protein; cord blood; delivery mode; asphyxia; brain damage
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