ORIGINAL ARTICLE

Plasma bilirubin level and oxidative stress in preterm infants

C Dani¹, E Martelli¹, G Bertini¹, M Pezzati¹, L Filippi¹, M Rossetti², G Rizzuti² and F F Rubaltelli¹

¹ Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy
² Central Laboratory of Chemical-Clinical Analysis, Careggi University Hospital of Florence

Correspondence to:
Correspondence to:
Dr Dani, Division of Neonatology, Careggi University Hospital, University of Florence School of Medicine, Viale Morgagni, 85 Firenze, Italy;
cdani{at}cesit1.unifi.it

Objective: To assess the hypothesis that changes in plasma total bilirubin levels (Btot) can influence the antioxidant system and oxidative stress in preterm infants.

Methods: Twenty two healthy preterm infants who presented with visible non-haemolytic hyperbilirubinaemia were studied at the mean (SD) age of 3.7 (1.5) days. Btot, plasma total hydroperoxide concentration (TH), plasma protein SH group concentration, and total antioxidant capacity of the plasma (TAC) were measured at study entry and after 24 hours.

Results: Btot did not correlate with TH, TAC, or protein SH group concentration, but a significant correlation was found between TH and TAC, TH and protein SH groups, and TAC and protein SH groups, both at study entry and after 24 hours.

Conclusion: The decrease in plasma bilirubin was contemporary with an increase in plasma antioxidant capacity and decrease in oxidative stress in preterm infants. This may be the result of the pro-oxidant effect of haem oxygenase, mediated by iron release, which may outcompete the antioxidant properties of bilirubin.

Keywords: bilirubin; jaundice; antioxidant; oxidative stress; preterm

Abbreviations: Btot, plasma total bilirubin concentration; TAC, total antioxidant capacity of the plasma; TH, plasma total hydroperoxide concentration

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This article has been cited by other articles:

• Sedlak, T. W., Snyder, S. H. (2004). Bilirubin Benefits: Cellular Protection by a Biliverdin Reductase Antioxidant Cycle. Pediatrics 113: 1776-1782 [Full Text]