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Effect of a change in global metabolic rate on peripheral oxygen consumption in neonates

¹ Neonatal Unit, City General Hospital, Stoke on Trent, UK
² Centre for Science and Technology in Medicine, University of Keele, UK
³ The Medical School, Keele University, UK

Correspondence to:
Correspondence to:
Dr Spencer, Neonatal Unit, Maternity Building, North Staffordshire Hospital (City General), Newcastle Road, Stoke on Trent ST4 6QG, UK;
andy.spencer{at}nstaffsh.wmids.nhs.uk

Aim: To evaluate the effect of an induced change in global metabolic rate on peripheral oxygen consumption (VO₂) in healthy full term neonates.

Subjects and methods: Twenty four healthy full term neonates were studied. Peripheral VO₂ was measured by near infrared spectroscopy (NIRS) using arterial occlusion and measurement of the oxyhaemoglobin (HbO₂) decrement slope. Global VO₂ was measured by open circuit calorimetry. Global and peripheral VO₂ were measured in each neonate before and after a routine bath. Abdominal and forearm skin temperatures were also recorded.

Results: Nineteen neonates completed the study. Global VO₂ increased by 30.7% (p = 0.001), and peripheral VO₂ by 23.1% (p = 0.001). A correlation between the fractional changes in global and peripheral VO₂ was apparent (r = 0.76, p = 0.001). Abdominal skin temperature decreased by 0.8°C (p = 0.001), and forearm skin temperature by 0.6°C (p = 0.04).

Conclusions: Measurement of peripheral VO₂ using NIRS with arterial occlusion is responsive to conditions that increase global metabolic rate. Any change in global VO₂ must be taken into consideration during the interpretation of peripheral VO₂ measurements in neonates.

Keywords: oxygen consumption; metabolic rate; near infrared spectroscopy

Abbreviations: VO₂; oxygen consumption; NIRS, near infrared spectroscopy; HbO₂, oxygenated haemoglobin; HbT, total haemoglobin; CI, confidence intervals

This article has been cited by other articles:

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				Y Wickramasinghe and S A Spencer Quantification of peripheral oxygen consumption by near infrared spectroscopy Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2004; 89(5): F469 - F470. [Full Text] [PDF]