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Can polyclonal intravenous immunoglobulin limit cytokine mediated cerebral damage and chronic lung disease in preterm infants?

¹ Department of Paediatrics, Baylor College of Medicine, Houston, TX 77025, USA
² Department of Neonatology, Westmead Hospital, and Children’s Hospital at Westmead, Sydney, NSW 2145, Australia
³ The Royal infirmary of Edinburgh at Little France, Edinburgh, EH16 4SU, Scotland, UK
⁴ National Perinatal Epidemiology Unit, Institute of Health Services, Oxford, OX3 7LF, UK
⁵ Department of Child Health, Queen Mary’s Hospital for Children, Carshalton, Surrey SM5 1AA, UK
⁶ Department of Clinical Sciences at North Bristol (Orthopaedic Surgery), University of Bristol, Bristol BS10 5NB, UK
⁷ NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW 2006, Australia

Correspondence to:
Correspondence to:
Dr Mohan
Department of Paediatrics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77025, USA; suseela12{at}hotmail.com

ABSTRACT
Recent evidence suggests that inflammatory cytokines may play an important role in cerebral and pulmonary injury, especially in preterm infants. Immunomodulatory agents may help to limit such injury by reducing inflammation. Immunoglobulin has multiple anti-inflammatory properties and can modulate the inflammatory cytokine response. New evidence is required to test the hypotheses that prophylaxis or treatment with intravenous immunoglobulin may limit such inflammatory damage.

Keywords: cytokines; immunoglobulin; immunomodulation; inflammatory injury; preterm

Abbreviations: CLD, chronic lung disease; IL, interleukin; IVIG, intravenous immunoglobulin; TNF, tumour necrosis factor

This article has been cited by other articles:

				W. Tarnow-Mordi, D. Isaacs, D. H. Smart, B. Stenson, and K. Haque Neurodevelopmental Impairment and Neonatal Infections JAMA, February 23, 2005; 293(8): 932 - 932. [Full Text] [PDF]