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Archives of Disease in Childhood Fetal and Neonatal Edition 2004;89:F88
© 2004 Archives of Disease in Childhood Fetal and Neonatal Edition


CASE REPORT

Exhaled nitric oxide in chronically ventilated preterm infants

O Williams, R Y Bhat, P Cheeseman, G F Rafferty, S Hannam, A Greenough

Children Nationwide Regional Neonatal Intensive Care Centre, 4th floor Ruskin Wing, King’s College Hospital, London SE5 9RS, UK

Correspondence to:
Correspondence to:
Professor A Greenough
Children Nationwide Regional Neonatal Intensive Care Centre, 4th floor Ruskin Wing, King’s College Hospital, London SE5 9RS, UK; anne.greenough{at}kcl.ac.uk


ABSTRACT
Exhaled nitric oxide (eNO) levels were measured in eight ventilated infants, mean gestational age 25.8 (SD 1.7) weeks and postnatal age 55 (SD 39) days, before and after three days of dexamethasone treatment. The eNO levels fell from a mean of 6.5 (SD 3.4) to 4.2 (SD 2.6) parts per billion (p = 0.031) and the mean supplementary oxygen levels from 62% to 45% (p = 0.0078).


Keywords: exhaled nitric oxide; chronic lung disease; prematurity

Abbreviations: eNO, exhaled nitric oxide; ppb, parts per billion; CLD, chronic lung disease; BAL, bronchoalveolar lavage; iNOS, inducible nitric oxide synthetase







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