© 2004 Archives of Disease in Childhood Fetal and Neonatal Edition
ORIGINAL ARTICLE
Hydrofluoroalkane-beclomethasone versus chlorofluorocarbon-beclomethasone delivery in neonatal models
1 The Floating Hospital for Children, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, 02111, USA
2 Trudell Medical International, London, Ontario, Canada, N5V 5G4
Correspondence to:
Correspondence to:
Dr Cole
Department of Neonatology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02115, USA; ccole{at}bidmc.harvard.edu
Dose delivery of hydrofluoroalkane-beclomethasone and chlorofluorocarbon-beclomethasone was compared during in vitro neonatal simulations: mechanical ventilation with 40% and 100% relative humidity + Neonatal Chamber-Ventilator System/endotracheal tube; manual ventilation + Neonatal Chamber/endotracheal tube; "spontaneous breathing" + Neonatal Chamber/face mask without/with manual assistance. The delivery of hydrofluoroalkane-beclomethasone was significantly greater in each simulation.
Abbreviations: CFC-BDP, chlorofluorocarbon-beclomethasone dipropionate; HFA-BDP, hydrofluoroalkane-beclomethasone dipropionate
Keywords: aerosol therapy; inhalants; glucocorticoid; bronchopulmonary dysplasia
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