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Testosterone measurements in early infancy

¹ Bone & Endocrine Research Group, Department of Child Health, Royal Hospital For Sick Children, Yorkhill, Glasgow G3 8SJ, Scotland, UK
² Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow G4 0SF

Correspondence to:
Correspondence to:
Dr Wallace
Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow G4 0SF, Scotland, UK; MWallace{at}gri-biochem.org.uk

ABSTRACT
Circulating testosterone concentrations in infants measured by a direct chemiluminescent immunoassay (Bayer ADVIA Centaur) were compared with those measured by a traditional radioimmunoassay using solvent extraction. The results confirm that neonatal circulating testosterone concentrations are method dependent, and each laboratory should establish method related reference ranges especially if using a direct commercial immunoassay. The results indicate that the Bayer ADVIA Centaur procedure can be used reliably in neonates. Expected values for male and female infants < 10 days old were 2.5–11.1 (n  =  36) and 1.7–5.6 (n  =  36) nmol/l respectively. For older neonates (10–50 days) the ranges were 0.2–17.2 (n  =  42) and 0.1–1.5 (n  = 7) nmol/l respectively.

Keywords: intersex; sex differentiation; sex steroids; testosterone; assay methods