Arch. Dis. Child

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in ADC Online
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Burguet, A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Burguet, A
Related Collections
Right arrow Pregnancy
Right arrow Other respiratory medicine
Right arrow Drugs: respiratory system
Right arrow Perinatal
Right arrowRelated Article
Archives of Disease in Childhood Fetal and Neonatal Edition 2005;90:F41-F45
© 2005 Archives of Disease in Childhood Fetal and Neonatal Edition

ORIGINAL ARTICLE

Does smoking in pregnancy modify the impact of antenatal steroids on neonatal respiratory distress syndrome? Results of the Epipage study

A Burguet1,2, M Kaminski2, P Truffert3, A Menget1, L Marpeau4, M Voyer5, J C Roze6, B Escande7, G Cambonie8, J M Hascoet9, H Grandjean10, G Breart2, B Larroque2 on behalf of the Epipage Study Group

1 Department of Neonatology, University Hospital, Besançon, France
2 Epidemiological Research Unit on Perinatal and Women’s Health, INSERM U149, Villejuif, France
3 Department of Neonatology, University Hospital, Lille, France
4 Department of Obstetrics and Gynaecology, University Hospital, Rouen, France
5 Department of Neonatology, Institut de Puériculture, Paris, France
6 Department of Neonatology, University Hospital, Nantes, France
7 Department of Neonatology, University Hospital Strasbourg, France
8 Department of Pediatrics, University Hospital Montpellier, France
9 Department of Neonatology, University Hospital, Nancy, France
10 INSERM U558, Toulouse, France

Correspondence to:
Correspondence to:
Dr Burguet
Réanimation Infantile Polyvalente et Prématurés, Hôpital Saint-Jacques, Centre Hospitalier Universitaire, 25030 Besançon cedex, France; a.burguet{at}chu-poitiers.fr

Objectives: To assess the relation between cigarette smoking during pregnancy and neonatal respiratory distress syndrome (RDS) in very preterm birth, and to analyse the differential effect of antenatal steroids on RDS among smokers and non-smokers.

Design: A population based cohort study (the French Epipage study).

Setting: Regionally defined births in France.

Methods: A total of 858 very preterm liveborn singletons (27–32 completed weeks of gestation) of the French Epipage study were included in this analysis. The odds ratio for RDS in relation to smoking in pregnancy was estimated using a logistic regression to control for gestational age. The odds ratio for RDS in relation to antenatal steroids was estimated taking into account an interaction between antenatal steroids and cigarette smoking, using multiple logistic regression to control for gestational age, birthweight ratio, main causes of preterm birth, mode of delivery, and sex.

Results: The odds ratio for RDS in relation to smoking in pregnancy adjusted for gestational age (aOR) was 0.59 (95% confidence interval (CI) 0.44 to 0.79). The aOR for RDS in relation to antenatal steroids was 0.31 (95% CI 0.19 to 0.49) in babies born to non-smokers and 0.63 (95% CI 0.38 to 1.05) in those born to smokers; the difference was significant (p = 0.04).

Conclusions: Cigarette smoking during pregnancy is associated with a decrease in the risk of RDS in very preterm babies. Although antenatal steroids reduce the risk of RDS in babies born to both smokers and non-smokers, the reduction is smaller in those born to smokers.

Abbreviations: PPROM, preterm premature rupture of membranes; RDS, respiratory distress syndrome

Keywords: antenatal steroids; respiratory distress syndrome; smoking in pregnancy


Related Article

Fantoms
Martin Ward Platt
Arch. Dis. Child. Fetal Neonatal Ed. 2005 90: F1. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 PediatricsHome page
R. Vieux, J. Fresson, J.-M. Hascoet, B. Blondel, P. Truffert, J.-C. Roze, J. Matis, G. Thiriez, C. Arnaud, L. Marpeau, et al.
Improving Perinatal Regionalization by Predicting Neonatal Intensive Care Requirements of Preterm Infants: An EPIPAGE-Based Cohort Study
Pediatrics, July 1, 2006; 118(1): 84 - 90.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
ARCH DIS CHILD FETAL NEONATAL ED ED PRACTICE
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2005 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health