HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Read responses to this article Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in ADC Online Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Harrison, C M Articles by Andersen, C C Search for Related Content PubMed PubMed Citation Articles by Harrison, C M Articles by Andersen, C C

Exhaled breath measures of inflammation: are they useful in neonatal chronic lung disease?

Department of Paediatrics, Mercy Hospital for Women, Melbourne, Australia

Correspondence to:
Correspondence to:
Dr Andersen
Department of Paediatrics, Mercy Hospital for Women, Clarendon St, East Melbourne, Victoria 3002, Australia; candersen{at}mercy.com.au

ABSTRACT
Neonatal chronic lung disease is a common problem for surviving infants of extreme prematurity. Although the precise pathophysiology is still not known, it is clear that inflammation provides a common link that amplifies the injury to the premature lung. Current invasive measures of pulmonary inflammation include markers in blood and airway effluent, with the cellular composition of tracheal fluid being the "gold standard". In this article available exhaled breath measures, particularly nitric oxide, carbon monoxide, volatile hydrocarbons, and exhaled breath condensate, are reviewed with particular reference to sample collection, analysis, and common pitfalls as they apply to the ventilated premature newborn at risk of chronic lung disease. Although they have great potential, all measures require thorough validation before being used clinically.

Abbreviations: CLD, chronic lung disease; eNO, exhaled nitric oxide; eCO, exhaled carbon monoxide; EBC, exhaled breath condensate

Keywords: chronic lung disease; inflammation; preterm; breath hydrocarbons; nitric oxide; carbon monoxide

This article has been cited by other articles:

				F-C Cheah, B A Darlow, and C C Winterbourn Association of hydrogen peroxide in exhaled breath condensates from infants with respiratory distress syndrome with the development of chronic lung disease. Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2006; 91(2): F155 - F155. [Full Text] [PDF]

				I. Horvath, J. Hunt, P. J. Barnes, and On behalf of the ATS/ERS Task Force on Exhaled Bre Exhaled breath condensate: methodological recommendations and unresolved questions Eur. Respir. J., September 1, 2005; 26(3): 523 - 548. [Abstract] [Full Text] [PDF]

eLetters: