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Nasal potential difference increases with gestation in moderately preterm neonates on the first postnatal day

¹ Liverpool Women’s Hospital, Neonatal Unit, Crown Street, Liverpool L8 7SS, UK
² Institute of Child Health, University of Liverpool, Royal Liverpool Children’s Hospital, Alder Hey, Liverpool L12 2AP, UK

Correspondence to:
Correspondence to:
Dr Gaillard
Respiratory Unit, Royal Liverpool Children’s Hospital, Eaton Road, Liverpool L12 2AP; gaillard{at}liv.ac.uk

ABSTRACT
At birth the mammalian airway switches from liquid secretion to absorption, an important mechanism in lung liquid clearance. Airway ion transport was examined on the first postnatal day in 38 moderately preterm infants (29–36 weeks gestation). The absorptive airway ion transport capacity was well developed regardless of respiratory condition and there was little capacity for Cl^– secretion.

Abbreviations: ENaC, epithelial sodium channel; PD, potential difference

Keywords: airway epithelium; chloride transport; epithelial sodium channel; respiratory distress; sodium transport