HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in ADC Online Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Brooks, J M Articles by Simmer, K Search for Related Content PubMed PubMed Citation Articles by Brooks, J M Articles by Simmer, K

Is surgical ligation of patent ductus arteriosus necessary? The Western Australian experience of conservative management

¹ Women’s and Children’s Health Service, Western Australia and *University of Western Australia
² Women and Infants Research Foundation and University of Western Australia

Correspondence to:
Correspondence to:
Dr Patole
Department of Neonatal Paediatrics, King Edward Memorial Hospital, Bagot Road, Subiaco, Western Australia 6008; Sanjay.Patole{at}health.wa.gov.au

Background: Surgical ligation of patent ductus arteriosus (PDA) is widely practised in preterm infants despite no clear evidence that this improves outcomes. Geographical isolation meant that ductal ligation was not an option in King Edward Memorial Hospital until recently.

Objective: A retrospective data analysis to test the hypothesis that outcomes of infants with persistent PDA were no worse than those of infants with no significant duct or a duct that closed after medical treatment.

Patients and Methods: A total of 252 infants (gestation 28 weeks) born between 1 January 2000 and 30 June 2002 were divided into three groups: group 1, no significant PDA (n = 154); group 2, significant PDA which closed after medical treatment (n = 65); group 3, significant PDA remaining patent after medical treatment (n = 33). A significant PDA was defined by a left atrium to aortic root ratio of >1.4 or a ductal diameter >1.5 mm with a left to right shunt.

Results: Twenty four (10%) infants died at median (interquartile range) 15.5 (9–35) days. After adjustment for gestational age, relative to group 1, the infants from group 3 were at a 4.02 times increased risk of death (95% confidence interval 1.12 to 14.51). There was no significant difference between groups in the incidence of chronic lung disease, chronic lung disease or death, necrotising enterocolitis, intraventricular haemorrhage, duration of oxygen, or hospital stay.

Conclusion: Mortality was higher in infants with a persistent PDA, but other morbidities were not significantly different. A randomised trial is needed to determine whether surgical ligation will reduce mortality in such infants.

Abbreviations: CLD, chronic lung disease; CRIB, clinical risk index for babies; IVH, intraventricular haemorrhage; NEC, necrotising enterocolitis; PDA, patent ductus arteriosus

Keywords: patent ductus arteriosus; surgical ligation; mortality; chronic lung disease

This article has been cited by other articles:

				A. M. Gaca, J. J. Jaggers, L. T. Dudley, and G. S. Bisset III Repair of Congenital Heart Disease: A Primer--Part 2 Radiology, July 1, 2008; 248(1): 44 - 60. [Abstract] [Full Text] [PDF]

				P. Roberts, S. Adwani, N. Archer, and N. Wilson Catheter closure of the arterial duct in preterm infants Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2007; 92(4): F248 - F250. [Abstract] [Full Text] [PDF]

				N. Chorne, C. Leonard, R. Piecuch, and R. I. Clyman Patent Ductus Arteriosus and Its Treatment as Risk Factors for Neonatal and Neurodevelopmental Morbidity Pediatrics, June 1, 2007; 119(6): 1165 - 1174. [Abstract] [Full Text] [PDF]

				S K Patole, V Kumaran, J N Travadi, J M Brooks, and D A Doherty Does patent ductus arteriosus affect feed tolerance in preterm neonates? Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2007; 92(1): F53 - F55. [Abstract] [Full Text] [PDF]

				S. Manzar High-Dose Indomethacin for Patent Ductus Arteriosus Closure: How Strong Is the Evidence? Pediatrics, May 1, 2006; 117(5): 1863 - 1863. [Full Text] [PDF]

				M. Sperandio, B. Beedgen, and O. Linderkamp High-Dose Indomethacin for Patent Ductus Arteriosus Closure: How Strong Is the Evidence?: In Reply Pediatrics, May 1, 2006; 117(5): 1863 - 1864. [Full Text] [PDF]

				P W Fowlie Managing the baby with a patent ductus arteriosus. More questions than answers? Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2005; 90(3): F190 - f190. [Full Text] [PDF]