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Are ethnic differences in lung function explained by chest size?

¹ Department of Child Health, Leicester Warwick Medical School, UK
² Department of Epidemiology and Public Health, University of Leicester, UK
³ Institute for Lung Health, Leicester, UK

Correspondence to:
Correspondence to:
Dr C Beardsmore
Department of Child Health, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester Royal Infirmary, PO Box 65, Leicester LE2 7LX, UK; csb{at}le.ac.uk

Background: Ethnic differences in lung function (LF) are recognised in adults and children. Most prediction equations for LF are derived from whites, so non-whites are at risk of erroneous assessment. It was hypothesised that differences in chest dimensions would explain differences in LF between Asian (Indian) and white schoolchildren.

Aims: To quantify the impact of chest dimensions on LF, which would inform our understanding of ethnic differences that have implications for health care.

Methods: Children aged 6–11 were studied in school. A questionnaire provided information on ethnicity and respiratory health. Spirometry was used to record FVC, FEV₁, FEF_25–75, and PEF. Weight, height, sitting height, and chest dimensions (chest height, circumference, antero-posterior and transverse diameters) were measured.

Results: Data were obtained from 294 healthy children. Standing height was the most important predictor of LF. Ethnicity was an independent predictor for all LF measures except PEF, where the effect was marginal. FVC in whites was 13.4% bigger than in Asians of the same height, and the FEV₁ was 10.6% greater in whites. The influence of chest dimensions on lung function was trivial. Body mass index was smaller in Asians but did not explain differences in LF.

Conclusions: Differences in chest dimensions did not explain the substantial effect of ethnicity on LF. Mechanisms whereby ethnicity exerts its influence may include differences in inspiratory muscle strength or lung compliance but remain speculative. Nevertheless it remains imperative that ethnic differences are recognised when interpreting LF tests.

Abbreviations: BMI, body mass index; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; LF, lung function; PEF, peak expiratory flow

Keywords: forced expiratory volume; forced expiratory flow rates; thorax; growth