ORIGINAL ARTICLE

Cognitive development in low risk preterm infants at 3–4 years of life

B Caravale¹, C Tozzi², G Albino² and S Vicari¹

¹ IRCCS, Ospedale Pediatrico Bambino Gesù, Santa Marinella, Roma, Italy
² Dipartimento di Ginecologia, Perinatologia e Puericultura, Università "La Sapienza", Roma, Italy

Correspondence to:
Correspondence to:
B Caravale
UOS di Neurologia e Riabilitazione, IRCCS, Ospedale Pediatrico Bambino Gesù, Lungomare Guglielmo Marconi 36, I-00058, Santa Marinella, Rome, Italy; bcaravale{at}libero.it

Background: Major neurological handicaps and neuropsychological disturbances are more common in ex-preterm children than their counterparts born at term.

Objective: To establish in a prospective study whether a characteristic neuropsychological profile exists in ex-preterm children who do not exhibit neurodevelopmental deficits on routine clinical examination.

Methods: Thirty intellectually normal children born preterm (30–34 weeks gestation) without major neurological disabilities and a control group of term children matched for age, sex, and parental educational and occupational status were assessed at 3–4 years of age to obtain a complete neuropsychological profile. Intellectual ability, language comprehension and expression, perceptual and visual motor function, working memory, and attention and behavioural problems were investigated.

Results: Even in the absence of major neurological signs, children born preterm achieved lower mean scores than controls on the Stanford-Binet intelligence scale (110.8 v 121, p<0.001), visual perception test (33.8 v 42.7, p<0.001), visual motor integration test (42.6 v 47.4, p = 0.049), memory for location test (8.4 v 9.5, p = 0.007), sustained attention test (41.6 v 51.5, p = 0.009), and the picture vocabulary test (33.3 v 44.7, p = 0.021).

Conclusions: Neuropsychological abnormalities can be detected early in childhood in apparently normal ex-preterm children and are consistent with a growing body of evidence that prematurity may be associated with long term neuropsychological morbidity in childhood and adolescence.

Abbreviations: ELBW, extremely low birthweight; IQ, intelligence quotient; LBW, low birthweight; VLBW, very low birthweight

Keywords: preterm; low birth weight; outcome; cognitive; neuropsychological assessment

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Mangham, L. J., Petrou, S., Doyle, L. W., Draper, E. S., Marlow, N. (2009). The Cost of Preterm Birth Throughout Childhood in England and Wales. Pediatrics 123: e312-e327 [Abstract] [Full Text]  
• Beauchamp, M. H., Thompson, D. K., Howard, K., Doyle, L. W., Egan, G. F., Inder, T. E., Anderson, P. J. (2008). Preterm infant hippocampal volumes correlate with later working memory deficits. Brain 131: 2986-2994 [Abstract] [Full Text]