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Therapeutic hypothermia following perinatal asphyxia

Division of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK

Correspondence to:
Correspondence to:
A D Edwards
Imperial College London, Hammersmith Campus, Du Cane Rd, London, W12 ONN, UK; David.Edwards{at}imperial.ac.uk

ABSTRACT
Well constructed and carefully analysed trials of hypothermic neural rescue therapy for infants with neonatal encephalopathy have recently been reported. The data suggest that either selective head cooling or total body cooling reduces the combined chance of death or disability after birth asphyxia. However, as there are still unanswered questions about these treatments, many may still feel that further data are needed before health care policy can be changed to make cooling the standard of care for all babies with suspected birth asphyxia.

Abbreviations: aEEG, amplitude integrated EEG; GMF, gross motor function; ICE, Infant Cooling Evaluation; MRC, Medical Research Council; NICHD, National Institute of Child Health and Human Development; PDI, psychomotor developmental index

Keywords: brain cooling; hypothermia; neuroprotection

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Arch. Dis. Child. Fetal Neonatal Ed. 2006 91: F79. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				H. Kirpalani, J. Barks, K. Thorlund, and G. Guyatt Cooling for Neonatal Hypoxic Ischemic Encephalopathy: Do We Have the Answer? Pediatrics, November 1, 2007; 120(5): 1126 - 1130. [Full Text] [PDF]

				J. S. Wyatt, P. D. Gluckman, P. Y. Liu, D. Azzopardi, R. Ballard, A. D. Edwards, D. M. Ferriero, R. A. Polin, C. M. Robertson, M. Thoresen, et al. Determinants of Outcomes After Head Cooling for Neonatal Encephalopathy Pediatrics, May 1, 2007; 119(5): 912 - 921. [Abstract] [Full Text] [PDF]

				D. J. Wilkinson, D. Casalaz, A. Watkins, C. C. Andersen, and T. Duke Hypothermia: A Neuroprotective Therapy for Neonatal Hypoxic-Ischemic Encephalopathy Pediatrics, February 1, 2007; 119(2): 422 - 423. [Full Text] [PDF]

				M A Bhat Re: Therapeutic hypothermia following perinatal asphyxia. Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2006; 91(6): F464 - F464. [Full Text] [PDF]

				A J A Ziino Palliation bias is being overlooked in neonatal hypothermia trials. Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2006; 91(6): F464 - F465. [Full Text] [PDF]

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