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Oesophageal atresia and tracheo-oesophageal fistula

Departments of Paediatric Surgery and Paediatric Respiratory Medicine, Royal Liverpool Children’s Hospital (Alder Hey), and Department of Child Health, University of Liverpool, UK

Correspondence to:
Correspondence to:
ProfessorLosty
Institute of Child Health, Royal Liverpool Children’s Hospital (Alder Hey), Eaton Road, Liverpool L12 2AP, UK; paul.losty{at}liv.ac.uk

ABSTRACT
Oesophageal atresia-tracheo-oesophageal fistula has featured in paediatric surgery since its beginnings. The first successful primary repair was in 1941. With overall survival now exceeding 90% in dedicated centres, the emphasis has changed to reducing morbidity and achieving improvements in the quality of life. An overview of current and emerging strategies in managing patients with this condition is presented. Advances in developmental biology and molecular genetics reflecting improved understanding of the pathogenesis are highlighted.

Abbreviations: OA, oesophageal atresia; TOF, tracheo-oesophageal fistula

Keywords: oesophageal atresia; tracheo-oesophageal fistula; outcomes; surgery