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Circulating levels of adiponectin in preterm infants

¹ First Department of Pediatrics, Athens University Medical School, Athens, Greece
² Department of Clinical Biochemistry, "Aghia Sophia" Children’s Hospital, Athens, Greece

Correspondence to:
Correspondence to:
Dr Tania Siahanidou
Neonatal Unit, First Department of Pediatrics, Athens University Medical School, "Aghia Sophia" Children’s Hospital, 115 27 Athens, Greece; neonat5{at}paidon-agiasofia.gr

Objective: To determine circulating levels of adiponectin in preterm infants and examine possible associations with anthropometric measurements, weight gain, and leptin and insulin levels.

Design: Prospective study.

Setting: A university hospital neonatal care unit.

Study population: 62 preterm (mean (SD) gestational age 32.0 (2.1) weeks) and 15 full-term infants (reference group).

Interventions: Blood samples taken at discharge (40.9 (14.8) days of life) from the preterm infants and at a comparable postnatal age in full-term infants. All infants were fed the same commercial formula, but in nine preterms the formula contained long-chain polyunsaturated fatty acids (LCPUFAs).

Main outcome measures: Serum levels of adiponectin, leptin and insulin. Associations of adiponectin levels were tested only in the preterm group.

Results: Serum levels of adiponectin were lower in preterm (40.9 (14.8) µg/ml) than full-term infants (53.1 (16.0) µg/ml, p<0.01). However, after adjustment for body weight, the influence of prematurity on adiponectin levels was no longer significant. In preterm infants, adiponectin levels independently correlated with being born small for gestational age (SGA) (ß = –0.35, p = 0.01), weight gain (ß = 0.28, p = 0.03) and LCPUFA-supplemented formula (ß = 0.34, p = 0.009). Serum adiponectin levels did not correlate with insulin or leptin levels. However, insulin levels were higher in preterm than in full-term infants after adjustment for body weight.

Conclusions: Adiponectin levels are lower in preterm infants at discharge than full-term infants probably due to decreased adiposity. The levels are influenced by being born SGA, weight gain and, possibly, by dietary LCPUFAs. The importance of these findings in the development of insulin or leptin resistance in children born prematurely needs to be further studied.

Abbreviations: AGA, appropriate for gestational age; SGA, small for gestational age; LCPUFA, long-chain polyunsaturated fatty acid

Keywords: adiponectin; leptin; insulin; preterm infants