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Renovascular hypertension commencing during fetal life

¹ Departments of Paediatric Nephrology, Royal Victoria Infirmary, Newcastle, UK
² Departments of Pathology, Royal Victoria Infirmary, Newcastle, UK

Correspondence to:
Correspondence to:
Malcolm G Coulthard
Departments of Paediatric Nephrology, Royal Victoria Infirmary, Newcastle, NE1 4LP; malcolm.coulthard{at}nuth.nhs.uk

ABSTRACT
We report three infants with severe, early hypertension due to unilateral renovascular disease, whose cardiovascular changes, or polycythaemia, or both, indicated they had been affected as fetuses. All underwent unilateral nephrectomy, and had a similar histology, with patchy areas having relatively normal glomeruli but immature proximal tubules. This pattern may be a marker for renovascular disease in fetal life.

Abbreviations: DMSA, dimercaptosuccinic acid; EMA, epithelial membrane antigen; FENa, fractional excretion of sodium