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Published Online First: 21 September 2006. doi:10.1136/adc.2006.104919
Archives of Disease in Childhood - Fetal and Neonatal Edition 2007;92:F301-F304
Copyright © 2007 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.

SHORT REPORT

Renovascular hypertension commencing during fetal life

Shivaram Hegde1, Christopher Wright2, Mohan Shenoy1, Nadeem E Moghal1 and Malcolm G Coulthard1

1 Departments of Paediatric Nephrology, Royal Victoria Infirmary, Newcastle, UK
2 Departments of Pathology, Royal Victoria Infirmary, Newcastle, UK

Correspondence to:
Correspondence to:
Malcolm G Coulthard
Departments of Paediatric Nephrology, Royal Victoria Infirmary, Newcastle, NE1 4LP; malcolm.coulthard{at}nuth.nhs.uk

ABSTRACT

We report three infants with severe, early hypertension due to unilateral renovascular disease, whose cardiovascular changes, or polycythaemia, or both, indicated they had been affected as fetuses. All underwent unilateral nephrectomy, and had a similar histology, with patchy areas having relatively normal glomeruli but immature proximal tubules. This pattern may be a marker for renovascular disease in fetal life.

Abbreviations: DMSA, dimercaptosuccinic acid; EMA, epithelial membrane antigen; FENa, fractional excretion of sodium


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