Archives of Disease in Childhood - Fetal and Neonatal Edition 2009;94:F51-F53
SHORT REPORTS
Arterial oxygen tension (Pao2) values in infants <29 weeks of gestation at currently targeted saturations
Neonatal Unit, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Scotland
Correspondence to:
Dr D Quine, Neonatal Unit, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh EH16 4SU, Scotland, UK; david.quine{at}luht.scot.nhs.uk
Background: Oxygen saturation (SpO2) monitors are commonly used to determine the need for supplemental oxygen. We aimed to describe the range of arterial oxygen tensions (PaO2) observed in preterm infants at saturation levels targeted in current trials.
Methods: In a cohort of 98 consecutive infants born at <29 weeks’ gestation, the PaO2 from each arterial blood gas result during the first week of life (n = 2076) was matched to the SpO2 at time of sampling. The mean (95% CI) PaO2 was calculated for each saturation.
Results: The 95% CI of PaO2 for the SpO2 range 85–95% was 3.8 to 8.9 kPa. The mean (95% CI) PaO2 at a saturation of 85% was 5.3 (3.8 to 6.8) kPa and at a saturation of 95% it was 7.2 (5.5 to 8.9) kPa.
Conclusion: Saturations within the range 85–95% largely exclude hyperoxia in preterm infants <29 weeks’ gestation but permit PaO2 values far lower than those recommended in traditional guidelines.
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Arch. Dis. Child. Fetal Neonatal Ed. 2009 94: F1.[Extract] [Full Text] [PDF]
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