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Archives of Disease in Childhood - Fetal and Neonatal Edition 2000;82:F171; doi:10.1136/fn.82.2.F171b
Copyright © 2000 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.
Arch Dis Child Fetal Neonatal Ed 2000;82:F171 ( March )

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Bilirubin and lipid peroxidation
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Bilirubin and lipid peroxidation

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EDITOR---I read the interesting article by Yigit et al about the lipid peroxidation in the first 10 days of life.1 A few points need explanation. Table 1 showed the range for collecting control group samples as 2-10 days, which contradicts the statement of the authors that samples were drawn on the day of admission.

Secondly, the mode of delivery was not mentioned. Rogers et al have reported higher levels of malondialdehyde (MDA) in cord blood after labour as compared with caesarean section,2 so the higher levels in the study group might have been because they were delivered vaginally.

Thirdly, the range for MDA in study and control groups was 2.5-22.5 µmol/l and 3.8-10.5 µmol/l, respectively. What is the normal range?

Finally, if there is a positive correlation between MDA and bilirubin, why did none of the neonates in the control group have any evidence of clinical jaundice?

With all these . . . [Full text of this article]


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