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The most recent version of this article was published on 1 January 2006

Arch. Dis. Child. Fetal Neonatal Ed.. Published Online First: 13 September 2005. doi:10.1136/adc.2004.066290
Copyright © 2005 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health
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Original articles

Developmental outcome in newborn infants treated for acute respiratory failure with ECMO: Present experience

Kiran Khambekar 1, Sanjiv Nichani 1, David K Luyt 1, Giles J Peek 1, Richard K Firmin 1, David J Field 1 and Hitesh C Pandya 1*

1 University Hospitals Leicester, United Kingdom

* To whom correspondence should be addressed. E-mail: hp28{at}le.ac.uk.

Accepted 16 July 2005


*   Abstract

Objective:To describe the later health status of newborns who received extracorporeal membrane oxygenation (ECMO) therapy for acute respiratory failure in the post UK ECMO trial1 era

Design:Prospective follow-up study of newborns who received ECMO at single centre between January 1997 and January 2001.

Setting:Departments of ECMO & Paediatric Intensive Care, University Hospitals of Leicester

Patients:All babies who received ECMO within 14 days of birth

Interventions:Neuro-development screening using the Schedule for growing Skills-II (SGS-II) assessment tool

Main outcome measures:Survival at 12 months of age by disease and functional development at follow-up.

Results:145 neonates received ECMO therapy for treatment of respiratory failure. 108 (75%) infants were alive at 1 year of age. There were no deaths in children treated for respiratory failure secondary to meconium aspiration syndrome (73 / 145). 93 (86% of survivors) children attended a follow-up visit at 11-19 months postnatal age. 82 children were classed as normal, 7 as having 'impairment' and 4 as having 'severe disability'.

Conclusions:Most newborn infants with acute respiratory failure treated with ECMO therapy will have a normal neuro-development screening assessment between 11 and 19 months of postnatal age. There is no evidence to suggest that changes in neonatal practice since the UK ECMO trial¹ have led to changes in outcome of infants undergoing ECMO therapy.

Keywords: ECMO, development, neonates, outcome, respiratory




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