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The most recent version of this article was published on 1 September 2005

Arch. Dis. Child. Fetal Neonatal Ed.. Published Online First: 4 May 2005. doi:10.1136/adc.2004.069328
Copyright © 2005 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health

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Original articles

Venepuncture is preferable to heel lance for blood sampling in term neonates

Satoru Ogawa 1, Tohru Ogihara 1*, Emi Fujiwara 1, Kazumi Ito 1, Mutsumi Nakano 1, Satsuki Nakayama 1, Tomomi Hachiya 1, Naomi Fujimoto 1, Hiroko Abe 1, Satoko Ban 1, Etsuko Ikeda 1 and Hiroshi Tamai 1

1 Osaka Medical College, Japan

* To whom correspondence should be addressed. E-mail: ped025{at}poh.osaka-med.ac.jp.

Accepted 7 March 2005


*   Abstract

Background:The analgesic effect of oral sucrose is generally accepted in newborn infants undergoing painful procedures. For blood sampling, some studies have shown that venepuncture (VP) is less painful than heel lance (HL).

Objective:To determine the least painful and the most effective method among blood sampling by VP or HL with or without sucrose.

Design:Randomized, double-blind placebo- controlled trial.

Subjects:One hundred healthy full-term newborn infants who underwent screening for inborn errors metabolism were randomly allocated to one of four experimental groups (25 infants each).

Intervention and outcome measure:Seven specially trained nurses performed blood sampling in turn at 2 minutes after administration of oral sucrose or water. Neonatal pain was assessed by the Neonatal Facial Coding System (NFCS), as well as by crying.

Results:Without sucrose, the NFCS score was higher in the HL group than the VP group during blood sampling (median: 58 vs. 23, p<0.001). Oral sucrose significantly reduced the score of the HL group (58 vs. 47, p<0.01) and also tended to reduce the score of the VP group (23 vs. 2, p<0.1). However, the HL with sucrose group still had a higher score than the VP without sucrose group (47 vs. 23, p<0.01). Crying and the total procedure time showed the same trends as the NFCS score.

Conclusions:VP is less painful and more effective than HL for blood sampling in newborn infants. Although oral sucrose may have an additive analgesic effect, it is not necessarily required if VP is used for blood sampling.


Keywords: Analgesia, Heel lance, Pain, Sucrose, Venepuncture




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L. Codipietro, M. Ceccarelli, and A. Ponzone
Breastfeeding or Oral Sucrose Solution in Term Neonates Receiving Heel Lance: A Randomized, Controlled Trial
Pediatrics, September 1, 2008; 122(3): e716 - e721.
[Abstract] [Full Text] [PDF]




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