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Arch Dis Child Fetal Neonatal Ed 76:F3-F8 doi:10.1136/fn.76.1.F3
  • Original article

Surfactant improves lung function and mitigates bacterial growth in immature ventilated rabbits with experimentally induced neonatal group B streptococcal pneumonia

Table 1

Characterisation of animals in the experimental groups; values are mean (SD)

Parameter Experimental group
GBS/1 minute (n=14) GBS/NaCl (n=22) GBS/Curosurf (n=22) NaCl/NaCl (n=20) NaCl/Curosurf (n=20)
Treatment 15 minutes GBS 5 ml/kg GBS 5 ml/kg GBS 5 ml/kg NaCl 5 ml/kg NaCl 5 ml/kg
Treatment 30 minutes Sacrificed at 16 minutes NaCl 2.5 ml/kg Curosurf 2.5 ml/kg NaCl 2.5 ml/kg Curosurf 2.5 ml/kg
Body weight (g) 35  (7) 37  (5) 35  (6) 36  (7) 36  (8)
Left lung weight (g) 0.40  (0.11) 0.32  (0.08) 0.35  (0.09) 0.31  (0.07) 0.34  (0.09)
Final survival time (minutes) 16  (0) 184  (93) 174  (105) 189  (90) 184  (108)
Heart rate (beats/minute) 195  (88) 74  (68) 129  (98) 111  (97) 144  (108)
pCO2 (kPa) 11.2  (3.6) 8.3  (4.1) 7.5  (2.9) 7.5  (3.6) 7.8  (4.3)

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