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Arch Dis Child Fetal Neonatal Ed 77:F52-F56 doi:10.1136/fn.77.1.F52
  • Original article

Developmental pattern of 3-oxo-Δ4 bile acids in neonatal bile acid metabolism

Table 3

Mean (SD) bile acids in faeces of healthy infants

Bile acid (μmol/g) 0 days (n=5) 7 days (n=6) 1 month (n=2) 3 months (n=5)
Usual bile acids 4.31 (3.55)3-a 1.35 (0.29) 1.70 (0.17) 1.94 (0.61)
% in total bile acids (27.64 (9.81)) (21.52 (6.47)) (29.36 (7.75)) (31.36 (13.88))
Fetal bile acids 4.41 (1.94)b 1.99 (0.60) 2.39 (0.95) 2.69 (1.29)
% in total bile acids (32.65 (11.06)) (31.68 (11.35)) (39.68 (9.32)) (38.33 (11.05))
Ursodeoxycholic acid 0.31 (0.09) 0.36 (0.18) 0.23 (0.01) 0.32 (0.09)
% in total bile acids (2.41 (0.92)a c) (5.23 (1.44)) (3.86 (0.54)) (5.42 (3.32))
3-oxo-Δ1 bile acid 0.93 (0.54) 0.70 (0.32) 0.82 (0.02) 0.66 (0.25)
% in total bile acids (6.44 (1.47)a c d) (10.59 (3.10)) (14.01 (2.77)c) (9.72 (1.67))
3-oxo-Δ4 bile acids 4.27 (2.10)a e f 2.29 (1.63) 0.79 (0.23) 1.07 (0.51)
% in total bile acids (30.86 (16.28)) (30.98 (14.97)) (13.09 (1.73)) (15.17 (5.01))
Total bile acids 14.22 (6.86)b e f 6.69 (2.07) 5.92 (1.00) 6.67 (1.67)
  • Usual bile acids: CA, CDCA, DCA, LCA. Fetal bile acids: CA-1β-ol, CDCA-1β-ol, HCA, Δ5-3β-ol. 3-oxo-Δ1 bile acid: Δ1-3-one. 3-oxo-Δ4 bile acids: Δ4-3-one, Δ4, 6-3-one.

  • 3-a P < 0.05 vs 7 days; b P < 0.01vs 7 days; c P < 0.05 vs 3 months; d P < 0.01 vs 1 month; eP < 0.05 vs 1 month, f P < 0.01vs 3 months .

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