Table 1

Clinical details of study infants

Case No	Gestational age (weeks)	Birthweight (g)	Clinical details	Inotropes	Cranial ultrasound at time of study	Cranial ultrasound at term	Outcome 12–18 months
1	24	864	Spontaneous preterm labour,	No	Small L IVH	Normal	Normal
			maternal candida amnionitis,
			mild hyaline membrane disease
2	24	810	Spontaneous preterm labour,	No	Normal	Normal	Squint related to ROP
			mild hyaline membrane disease
3	25	767	Spontaneous preterm labour,	No	Normal	Normal	Normal
			mild hyaline membrane disease
4	28	1130	Ruptured membranes 5 weeks,	No	Normal	Normal	Phasic ankle response
			spontaneous labour,
			mild hyaline membrane disease
5	24	700	Small placental abruption,	No	Small R IVH	Normal	Died
			vaginal delivery,				Necrotising enterocolitis
			mild hyaline membrane disease
6	27	1100	Twin 1,	Dopamine day 1	Normal	Normal	Normal
			spontaneous preterm labour,
			moderate hyaline membrane disease
7	27	990	Spontaneous preterm labour,	No	Normal	Normal	Normal
			mild hyaline membrane disease
8	26	825	Maternal PIH	No	Small R IVH	Normal	Asymmetry of ankle tone
			emergency Section, poor CTG,
			cord pH=6.8,
			moderate hyaline membrane disease
9	24	637	Breech delivery, maternal vaginal chlamydia, moderate hyaline membrane disease	No	Normal	Mild ventricular dilation	Normal
10	31	1443	Elective caesarean section,	No	Normal	Normal	Emigrated, lost to follow up
			maternal cranio-pharyngioma,
			severe hyaline membrane disease
11	30	1460	Emergency caesarean section, ante-partum haemorrhage, first pH 7.22, moderate hyaline membrane disease	No	Normal	Normal	Subtle neurological abnormalities

IVH=intraventricular haemorrhage; ROP=retinopathy of prematurity; PIH=pregnancy induced hypertension; CTG=cardiotocogram

Cerebral blood flow increases over the first three days of life in extremely preterm neonates

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