In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infants
- Department of Paediatrics, Division of Neonatology, University of Florida College of Medicine, P O Box 100296 Gainesville, FL, USA
- Dr Yai Li.
- Accepted 10 July 1997
Abstract
The in vitro effect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. Concentrations of 106M to 109M were associated with a dose dependent inhibition of colony formation, with the most clinically important effects seen on the earliest erythroid and granulocyte-macrophage colonies. Because of the potential clinical implications of these observations, studies are needed to determine the effects of dexamethasone on haematopoiesis in preterm infants.
