Table 2
Specific [3H]MK-801 binding in prefrontal cortex membranes from brains of adults, infants and neonates, and inhibition by Mg2+
| Adults | Infants | Neonates | |
|---|---|---|---|
| Non-stimulated binding | 292 ± 11 | 312 ± 17 | 249 ± 152-1 |
| Stimulated binding2-150 | 774 ± 28 | 933 ± 40 | 335 ± 382 |
| and % increase | +165 | +199 | +35 |
| Mg2+ IC50 - mM2-150 | 0.87 ± 0.1 | 1.4 ± 0.3 | 3.6 ± 1.33 |
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↵2-150 [3H]MK-801 binding was stimulated with 100 μM L-glutamate plus 10 μM glycine. Data values are mean ± SEM obtained with 6 adult brains, 6 infant brains or 5 neonatal brains.
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↵2-1 Data from neonates are significantly different from infant data (p < 0.05), or 2 both infant and adult data (p < 0.001), or 3 adult data (p < 0.05).
