Volume delivery during high frequency oscillation
- aChildren Nationwide Regional Neonatal Intensive Care Centre, King’s College Hospital, London, bDepartment of Paediatrics, United Medical and Dental Schools, St Thomas’ Hospital, London
- Professor A Greenough, Children Nationwide Regional Neonatal Intensive Care Centre, 4th floor, Ruskin Wing, King’s College Hospital, London SE5 9RS.
- Accepted 24 September 1997
Abstract
AIM To examine the delivered volume during “high volume strategy” high frequency oscillation, used as rescue treatment in preterm infants; and to identify factors, other than frequency and oscillatory amplitude, influencing the magnitude of volume delivery.
METHOD Twenty infants (median gestational age 29 weeks) were studied on 45 occasions. Two oscillator types were used (SensorMedics and SLE). Delivered volume was measured under clinical conditions with the arterial blood gases within a predetermined range. A specially calibrated pneumotachograph system was used.
RESULTS Overall, the median delivered volume was 2.4 ml/kg (range 1.0 to 3.6 ml/kg); on 32 occasions the delivered volume was greater than 2.0 ml/kg and on seven greater than 3.0 ml/kg. The delivered volume related significantly to disease severity; there was an inverse correlation between delivered volume and both the oxygenation index (OI) (r=−0.51) and AaDO2 (r=−0.54).
CONCLUSION Delivered volume during HFO may, in certain infants, exceed the anatomical dead space, permitting some direct alveolar ventilation.
