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Arch Dis Child Fetal Neonatal Ed 79:F100-F104 doi:10.1136/fn.79.2.F100
  • Original article

Randomised crossover trial of salbutamol aerosol delivered by metered dose inhaler, jet nebuliser, and ultrasonic nebuliser in chronic lung disease

Table 5

Respiratory system resistance before and after salbutamol aerosol

Device used Respiratory system resistance (cm H2O/ml/s): mean (SEM)
Before 15 min 30 min 60 min 120 min p5-150
Study 1:
1 (MDI) 0.339 (0.065) 0.229 (0.044) 0.175 (0.032) 0.225 (0.042) 0.278 (0.054) <0.00015-151
 2 (Jet) 0.349 (0.070) 0.262 (0.046) 0.226 (0.042) 0.284 (0.051) 0.331 (0.063) <0.00015-164
 3 (Ultrasonic) 0.369 (0.072) 0.202 (0.034) 0.146 (0.022) 0.219 (0.043) 0.298 (0.059) <0.00015-160
Study 2:
1 (MDI) 0.404 (0.052) 0.325 (0.041) 0.287 (0.037) 0.336 (0.041) 0.374 (0.048) <0.00015-151
 2 (Jet) 0.411 (0.057) 0.373 (0.052) 0.345 (0.050) 0.371 (0.051) 0.412 (0.054) <0.00015-151
 3 (Ultrasonic) 0.428 (0.062) 0.325 (0.047) 0.246 (0.035) 0.299 (0.040) 0.365 (0.047) <0.00015-151
  • 5-150 One way repeated measures ANOVA.

  • Multiple pairwise comparison by Student-Newman-Keul Method (p<0.05):

  • 5-151 30 min<15 min<60 min<120 min and before treatment;

  • 5-164 30 min<60 min<120 min and before treatment, 15 min<120 min<before treatment;

  • 5-160 30 min<15 and 60 min<120 min<before treatment.

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