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Arch Dis Child Fetal Neonatal Ed 80:F1-F7 doi:10.1136/fn.80.1.F1
  • Original article

Clinical outcomes of newborn screening for cystic fibrosis

Table 3

Mean differences between screened and non-screened group: cross sectional (CS) and longitudinal (L) data adjusted for pancreatic function (positive values indicate advantage for screened)

One year
Mean (95% CI) difference of estimate
Five years
Mean (95% CI) difference of estimate
10 years
Mean (95% CI) difference of estimate
All ages (95% CI) unadjusted
Height SDS
 CS 0.3 (−0.1, 0.7) 0.4 (0.1, 0.8) 0.4 (−0.1, 0.8)
 L 0.2 (−0.3, 0.7) 0.4 (−0.1, 0.8) 0.4 (−0.1, 0.8) 0.3 (−0.1, 0.7)
Weight SDS
 CS 0.5(0.2, 1.0) 0.4 (−0.1, 0.8) 0.3 (−0.1, 0.7)
 L 0.5 (0.1, 0.9) 0.2 (−0.2, 0.7) 0.3 (−0.1, 0.7) 0.4 (0.1, 0.7)
FEV1 (% predicted)
 CS 9.0 (2.6, 15.4) 9.4 (0.8, 17.9)
 L 7.3 (0.4, 14.3) 8.3 (−0.1, 16.6) 8.6 (2.1, 15.0)
FVC (% predicted)
 CS 8.5 (1.9, 15.2) 8.4 (1.8, 15.0)
 L 4.1 (−2.4, 10.7) 7.3 (1.1, 13.5) 6.5 (1.0, 11.9)
FEF25-75 (% predicted)
 CS 21.2 (9.0, 33.4) 9.3 (−5.7, 24.2)
 L 19.3 (5.8, 32.9) 8.0 (−7.1, 23.1) 13.2 (1.6, 24.7)
CXR score
 CS 1.0 (−0.4, 1.9) 1.2 (−0.1, 2.6) 1.0 (−1.0, 2.5)
 L 1.0 (−0.4, 2.2) 1.1 (−0.4, 2.6) 1.0 (−1.2, 2.4) 1.0 (−0.1, 1.9)
Shwachman score
 CS 2.4 (0.7, 4.1) 3.8(1.0, 4.1) 5.3 (1.2, 9.4)
 L 2.3 (0.4, 4.1) 2.8 (−0.3, 6.0) 5.0 (0.8, 9.2) 3.6 (1.4, 5.7)
  • SDS = standard deviation score. Student’s ttest: p<0.05 and p<0.01 for difference between screened and non-screened group.

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