Blood gas, pH, base excess, heart rate, PAP, SAP, and cerebral blood flow volume in newborn piglets with PPHN model during treatments
| Parameters | Group | Baseline | Before treatment | After treatment | Difference (after-before) |
|---|---|---|---|---|---|
| PaO2 (kPa) | Tz | 12.5 (0.5) | 4.0 (0.3)1-150 | 4.2 (0.4)1-150 | 0.19 (0.14) |
| HAT | 11.7 (0.7) | 4.1 (0.3)1-150 | 3.7 (0.1)1-150 | −0.40 (0.32) | |
| iNO | 12.1 (0.4) | 4.2 (0.2)1-150 | 4.4 (0.2)1-150 | 0.21 (0.29) | |
| PaCO2 (kPa) | Tz | 6.3 (0.3) | 6.1 (0.3) | 5.9 (0.3) | −0.21 (0.12) |
| HAT | 6.2 (0.1) | 6.6 (0.3) | 3.7 (0.1)** | −2.82 (0.33) | |
| iNO | 6.4 (0.2) | 6.4 (0.2) | 6.4 (0.2) | −0.03 (0.05) | |
| pH | Tz | 7.33 (0.02) | 7.32 (0.01) | 7.37 (0.02) | 0.05 (0.03) |
| HAT | 7.33 (0.01) | 7.31 (0.03) | 7.52 (0.01)** | 0.21 (0.03) | |
| iNO | 7.34 (0.02) | 7.36 (0.02) | 7.36 (0.02) | 0.003 (0.03) | |
| Base excess (mEq/l) | Tz | 0.1 (0.7) | −0.6 (1.2) | −0.4 (0.2) | 0.2 (1.4) |
| HAT | 0.4 (0.4) | −0.8 (1.2) | 0.0 (1.0) | 0.8 (0.7) | |
| iNO | 0.2 (1.0) | 1.8 (1.5) | 1.8 (1.5) | 0.0 (0.5) | |
| Heart rate (beats/min) | Tz | 220 (9) | 235 (10) | 222 (18) | −14.6 (6.4) |
| HAT | 220 (13) | 234 (7) | 257 (4) | 21.6 (7.3) | |
| iNO | 218 (9) | 247 (9) | 245 (10) | −1.6 (10.5) | |
| PAP (mm Hg) | Tz | 21.7 (1.4) | 37.9 (3.8)1-150 | 27.9 (3.3)† | −10.0 (1.5) |
| HAT | 21.1 (1.2) | 41.0 (1.8)1-150 | 28.6 (1.9)† | −12.4 (1.2) | |
| iNO | 20.7 (1.9) | 40.3 (2.7)1-150 | 29.5 (1.7)† | −10.8 (1.6) | |
| SAP (mm Hg) | Tz | 72.6 (2.5) | 89.6 (5.8) | 70.5 (5.6)‡ | −19.1 (1.9) |
| HAT | 84.5 (2.5) | 95.4 (7.4) | 79.2 (4.9) | −16.2 (4.7) | |
| iNO | 83.1 (4.8) | 97.4 (8.5) | 93.7 (9.2) | −3.7 (3.8) | |
| Cerebral blood flow (ml/min) | Tz | 43.3 (2.3) | 52.8 (1.5)1-150 | 47.3 (1.9) | −7.7 (0.7) |
| HAT | 37.8 (3.8) | 49.3 (1.4)1-150 | 30.1 (1.3)** | −19.2 (0.8) | |
| iNO | 36.9 (3.3) | 52.2 (4.5)1-150 | 50.5 (4.1) | −1.7 (1.3) |
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Mean (SEM), n=5.
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↵1-150 significant difference (p<0.01) to the baseline levels. **significant difference (p<0.01) between before and after treatment and between groups.† significant difference (p<0.01) between before and after treatment. ‡ significant difference (p<0.05) between before and after treatment.
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Tz: tolazoline infusion, HAT: hyperventilation alkalosis, iNO: inhaled nitric oxide, PAP: mean pulmonary arterial pressure, SAP: mean systemic arterial pressure.
