Table 1
Cases of ESBLKp sepsis
| Cases | Sex | Gestation (weeks) | Birthweight (kg) | Underlying problems | Antibiotics before ESBLKp sespis and days of use | Age at sepsis onset (days) | Date of ESBLKp sepsis | Sites of positive cultures | Empiric antibiotics | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 41 | 3.5 | Bladder extrophy | A2, G2, Am(oral)5 | 24 | 30/7/95 | Blood, urine | Ami, F | Survived |
| 2 | M | 40 | 3.7 | NEC (day 3) | A9. G9, M9 | 13 | 29/10/95 | Blood | Ctx, G then Ami (at 24 hours) | Survived |
| 3 | M | 34 | 2.0 | Malrotation; volvulus; NEC (day 25) | Cl 12, G14, A7, M4 | 60 | 19/1/96 | Blood | Ctx, G then Imi (at 24 hours) | Survived |
| 4 | F | 35 | 2.4 | Gastoschisis | A11, Ami11, M5, G5 | 56 | 27/1/96 | Blood | V, G then Ctx, G (at 24 hours) then Imi (1 dose) | Died |
| 5 | M | 29 | 1.2 | HMD | Nil | 6 | 3/3/96 | Blood | V, G | Died |
| 6 | F | 25 | 0.6 | CLD, FTT; NEC, multiple gut resections | Multiple courses | 195 | 3/3/96 | Blood | A, G then Imi (at 48 hours) | Survived |
| 7 | F | 37 | 2.82 | Cloacal extrophy; lipomyelo-meningocele | A6, G6, M4 | 6 | 11/3/96 | Blood, urine | Imi | Survived |
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HMD = hyaline membrane disease; CLD = chronic lung disease; FTT = failure to thrive; NEC = necrotising enterocolitis; ESBLKp = extended spectrum β-lactamase producing Klebsiella pneumoniae; A = ampicillin; Cl = clindamycin; Imi = imipenem; Am = amoxycillin; Ctx = cefotaxime; M = metronidazole; Ami = amikacin; F = flucloxacillin; V = vanomycin; G = gentamicin.
