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Arch Dis Child Fetal Neonatal Ed 80:F148-F154 doi:10.1136/fn.80.2.F148
  • Basic science

Plausible explanations for effects of long chain polyunsaturated fatty acids (LCPUFA) on neonates

Table 1

Sources and functions of fatty acids

n -3 series n- 6 series
Source Generally - vegetable oils; longer chained- fatty acids in phytoplankton and tranferred down the marine nutrition chain;α-linolenic acid (18:3n-3) also found in higher plant structural fats; eicosapentaenoic acid (20:5n-3) predominantly found in fish oils Generally derived from plants, grain and vegetable oils;linoleic acid (18:2 n-6) mainly in dietary vegetables and plant lipids - safflower, sunflower, soybean, borage, evening primrose; arachidonic acid (20:4n-6) predominantly in animal fats
Function Precursors of signal molecules, constituents of membrane phospholipids Precursors of signal molecules, constituents of membrane phospholipids
Derivatives Eicosanoids including series 5 leukotrienes LTB5, prostaglandins eg PGE3, PGI3, thromboxanes eg TxA3 Eicosanoids including leukotrienes eg LTB4, LTC4, prostaglandins eg PGE2, PGI2thromboxanes eg TxA2

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