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Arch Dis Child Fetal Neonatal Ed 80:F213-F216 doi:10.1136/fn.80.3.F213
  • Original article

Effect of multiple courses of antenatal corticosteroids on pituitary-adrenal function in preterm infants

Table 2

Plasma ACTH and serum cortisol concentrations before and after hCRH stimulation at days 7 and 14 in preterm infants whose mothers received eight or more doses of antenatal dexamethasone

ACTH (pmol/l) Cortisol (nmol/l)
0 min 15 mins 30 mins 60 mins 0 min 15 mins 30 mins 60 mins
Day 7 (n = 14) 5.1  (0.7) 11.5  (2.3) 8.4  (1.4) 6.3  (0.9) 283  (47) 450  (44) 552  (60) 347  (64)
Day 14 (n = 12) 7.9 (1.1) 12.0 (2.4) 10.2 (1.6) 8.3 (1.3) 371 (33) 453 (46) 552 (56) 374 (50)
Differences between days 14 and 7 (n = 12) 2.4 (1.3) 2.1 (2.3) 2.8 (1.3) 2.6 (1.1) 62 (61) -12 (78) -20 (86) 25 (96)
  • Values are mean (SEM)

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