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This article has a correction

Please see: Arch Dis Child Fetal Neonatal Ed 1999;81:F79

Arch Dis Child Fetal Neonatal Ed 1999;80:F235-F237 doi:10.1136/fn.80.3.F235
  • Original article

Serum malondialdehyde concentration in babies with hyperbilirubinaemia

  1. Šule Yiğita,
  2. Murat Yurdaköka,
  3. Kamer Kilinçb,
  4. Olcay Orana,
  5. Gülsen Erdema,
  6. Gülsevin Tekinalpa
  1. aDepartment Of Pediatrics Hacettepe University Hospital Ankara Turkey, bDepartment of Biochemistry
  1. Dr S Yiğit Ziraat Mühendisleri Sitesi 3 / 21 Çankaya 06650 Ankara Turkey.
  • Accepted 19 October 1998

Abstract

AIM To determine lipid peroxide concentrations in the first 10 days of life.

METHODS Malondialdehyde concentrations were investigated in neonates with or without hyperbilirubinaemia during the first 10 days of life.

RESULTS Serum malondialdehyde concentrations were higher in infants with hyperbilirubinaemia than in controls. A positive correlation was found between malondialdehyde and bilirubin concentrations in the study group. When the study group was categorised according to the presence of haemolysis, a significant correlation was found between malondialdehyde and bilirubin concentrations in those infants with hyperbilirubinaemia due to haemolysis. There was no such correlation in those without haemolysis.

CONCLUSION Exchange transfusion rapidly produces variable changes in pro-oxidant and antioxidant plasma concentrations in neonates, which may be responsible for free radical metabolism. The fall in malondialdehyde concentration is probably directly related to its exogenous removal by exchange transfusion.

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