Table 1
Virological, clinical, and neuroradiological data in 36 children with neonatal HSV infections
| Case No | Neonatal disease | HSV-DNA | Aciclovir/no treatment | CT/MRI/HUS | Follow up neurodevelopmental outcome/years | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CSF | S | ||||||||||
| Maternal primary HSV-1 infection, no previous HSV infection with either type | |||||||||||
| 1 | DISS* | ND | +(5) | None | ND | Normal+ keratitis/14y* | |||||
| 2 | CNS* | ND | +(7) | None | ND | Normal/14y | |||||
| 3 | CNS* | ND | +(4) | Aciclovir | ND | Normal/1y | |||||
| Maternal secondary HSV-1 infection (previous infection with HSV-1) | |||||||||||
| 4 | CNS* | − | +(4) | Aciclovir | Normal | Normal/ 7y* | |||||
| 5 | DISS* | ND | +(4) | None | ND | MMR/14y* | |||||
| External source HSV-1 infection (no maternal infection) | |||||||||||
| 6 | DISS | + | +(10) | Aciclovir | Normal | Normal/1y | |||||
| 7 | CNS* | + | +(1) | Aciclovir | Abnormal | Normal/1y | |||||
| Maternal primary HSV-2 infection, no previousHSV infection with either type | |||||||||||
| 8 | CNS | ND | −(6) | None | ND | CP/18y* | |||||
| 9 | DISS | ND | +(2) | None | ND | Dead/1w | |||||
| 10 | DISS | − | ND | None | ND | Dead/1w | |||||
| 11 | CNS | + | +(1) | Aciclovir | Abnormal | Dead/4y | |||||
| 12 | DISS,cong* | − | ND | Aciclovir | Abnormal | CP+SMR/2y* | |||||
| Maternal primary HSV-2, previous HSV-1 infection | |||||||||||
| 13 | CNS | ND | −(5) | None | ND | CP+SMR/8y | |||||
| 14 | CNS* | ND | −(3) | None | Abnormal | CP+SMR/14y* | |||||
| 15 | CNS* | − | −(6) | Aciclovir | ND | Normal/7y* | |||||
| 16 | CNS* | − | −(4) | Aciclovir | Abnormal | CP+SMR/11y* | |||||
| 17 | CNS* | + | ND | Aciclovir | Abnormal | CP+SMR/4y* | |||||
| 18 | CNS | + | −(2) | Aciclovir | Abnormal | CP/2y* | |||||
| Maternal secondary HSV-2 infection, (previous infection with HSV-2) | |||||||||||
| 19 | CNS* | ND | −(9) | None | Abnormal | CP/18y* | |||||
| 20 | CNS | − | +(4) | Aciclovir | Abnormal | CP+MMR/14y* | |||||
| 21 | CNS* | + | +(2) | Aciclovir | Abnormal | CP+SMR/12y* | |||||
| 22 | CNS | + | −(3) | Aciclovir | Abnormal | normal/10y* | |||||
| 23 | CNS* | + | +(3) | Aciclovir | Abnormal | CP/6y* | |||||
| 24 | CNS* | − | +(4) | Aciclovir | Abnormal | Normal+ keratitis/7y | |||||
| 25 | CNS* | + | +(6) | Aciclovir | Abnormal | Normal/1y* | |||||
| 26 | CNS | + | +(4) | Aciclovir | Abnormal | Normal /3.5y | |||||
| 27 | CNS | + | +(5) | Aciclovir | Abnormal | CP+SMR/6y* | |||||
| 28 | CNS | + | +(7) | Aciclovir | Abnormal | Normal/1.5y | |||||
| 29 | CNS | + | ND | Aciclovir | Abnormal | CP+/4y* | |||||
| 30 | CNS | + | +(6) | Aciclovir | Abnormal | CP+SMR/10y | |||||
| 31 | CNS | + | −(3) | Aciclovir | Abnormal | CP+SMR/8y* | |||||
| 32 | CNS | + | −(20) | Aciclovir | Abnormal | CP+SMR/10y* | |||||
| 33 | CNS | + | +(3) | Aciclovir | Abnormal | CP+SMR/7y | |||||
| 34 | CNS* | + | +(1) | Aciclovir | Abnormal | dead/2.5y | |||||
| 35 | SEM* | + | ND | Aciclovir | Normal | Normal+ keratitis/3y | |||||
| 36 | CNS | + | ND | Aciclovir | Abnormal | CP/1.5y | |||||
-
S = serum; CSF = cerebrospinal fluid;
-
1-151 figures in parentheses represent sampling day after onset of disease ND = no specimens/not done; CP = cerebral palsy; SMR/MMR = severe/mild mental retardation; Cong = congenital; Normal = No neurodevelopmental abnormality; CT/ MRI/HUS = computed tomography/ magnetic resonance imaging /head ultrasound; * = neonatal and/or subsequent recurrent vesicles.
