Table 1
Neuroblastoma in the neonatal period; characteristics of 33 tumours 1986–94
| Stage | Age at diagnosis (days) | Prenatal ultrasound | Presentation | Primary site | Other sites | Treatment | Outcome | Complications |
|---|---|---|---|---|---|---|---|---|
| 1 | 1 | Normal | Abdominal mass | Adrenal | Nil | S | Alive | |
| 1 | 2 | ? Neuroblastoma | Prenatal ultrasound | Adrenal | Nil | S | Alive | |
| 1 | 10 | Normal | Neck mass | Cervical | Nil | S | Alive | |
| 2 | 0 | Not documented | Tachycardia, sweaty, hypertensive | Abdominal | Nil | S | Alive | Infarcted left kidney post operatively |
| 2 | 15 | Not documented | Stridor | Cervical | Nil | S+C | Alive | |
| 2 | 16 | Not documented | Abdominal mass | Adrenal | LN | S | Alive | |
| 2 | 16 | Not documented | Lower limb neurology, incontinence | Intraspinal L1/L2 | Nil | S | Alive | Neuropathic bladder, walking aids |
| 2 | 18 | Not documented | Abdominal mass | Adrenal | Nil | S | Alive | |
| 3 | 0 | Not documented | Birth asphyxia | Thoracic | Paraspinal extension | S | Alive | Abnormal sweating |
| 3 | 6 | Normal | Abdominal mass | Adrenal | LN | S+C | Alive | |
| 3 | 11 | Not documented | Abdominal distension | Thoracic | Intraspinal extension | S+C | Alive | Kyphoscoliosis |
| 3 | 18 | Reduced movement of lower limbs | Lower limb neurology | Adrenal | Intraspinal extension | S+C | Alive | Flaccid paralysis lower limbs |
| 3 | 22 | Not documented | Lower limb neurology | Thoraco- abdominal |
LN, paraspinal extension | S+C | Alive | Scoliosis |
| 3 | 26 | Not documented | Respiratory distress | Thoracic | Intraspinal extension | S+C | Alive | Flaccid paralysis lower limbs |
| 3 | 27 | Not documented | Urinary dribbling | Adrenal | Intraspinal extension | S+C | Alive | Incontinent, walking aids |
| 4 | 0 | Normal | Hydrops | Adrenal | Liver, brain, heart, bone, muscle, lungs | Nil | Stillbirth | |
| 4 | 1 | ? Neuroblastoma | Abdominal distension, hydrops | Adrenal (bilateral) | Liver | C | Died | |
| 4 | 1 | ? Neuroblastoma | Prenatal ultrasound | Adrenal | Liver, BM, pleura | S+C | Alive | |
| 4 | 27 | Normal | Abdominal distension | Adrenal | Liver, BM, LN | S+C+BMT | Alive | High tone deafness |
| 4S | 0 | ? Neuroblastoma | Prenatal ultrasound | Adrenal | Liver | S | Alive | |
| 4S | 0 | ? Neuroblastoma | Prenatal ultrasound | Adrenal | Liver | C | Alive | Learning difficulties |
| 4S | 1 | Not documented | Skin nodules | Unknown | Skin | Nil | Died | |
| 4S | 2 | Not documented | Intestinal obstruction | Adrenal | Liver | S | Alive | |
| 4S | 2 | Not documented | Abdominal mass | Adrenal | Liver, LN | C | Alive | |
| 4S | 5 | Not documented | Abdominal distension | Adrenal | Liver | S+C+R | Alive | |
| 4S | 8 | Not documented | Abdominal mass | Adrenal | Liver | Nil | Alive | |
| 4S | 9 | Not documented | Abdominal mass | Liver | Liver | R | Alive | |
| 4S | 13 | Not documented | Abdominal mass | Adrenal | Liver, BM | Nil | Alive | |
| 4S | 14 | Cyst right kidney | Abdominal mass | Adrenal | Liver, BM | C | Alive | |
| 4S | 19 | Not documented | Skin nodules | Adrenal | Liver, BM, skin | Nil | Alive | |
| 4S | 21 | Not documented | Skin nodules | Adrenal | Liver, skin | Nil | Alive | |
| 4S | 26 | Not documented | Abdominal distension | Adrenal | Liver, BM | C | Alive | |
| 4S | 26 | Not documented | Abdominal mass | Adrenal | Liver | S | Alive |
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S = surgery; C = chemotherapy; R = radiotherapy; BMT = bone marrow transplant; LN = lymph nodes; BM = bone marrow.
