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Arch Dis Child Fetal Neonatal Ed 2000;83:F17-F20 doi:10.1136/fn.83.1.F17
  • Original article

Markers of collagen metabolism and insulin-like growth factor binding protein-1 in term infants

  1. T Hytinanttia,b,
  2. E-M Rutanenc,
  3. M Turpeinend,
  4. R Sorvad,
  5. S Anderssonb,c
  1. aHelsinki City Maternity Hospital, Helsinki, Finland, bThe Hospital for Children and Adolescents, Helsinki, Finland, cDepartment of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland, dDepartment of Allergology, Helsinki University Central Hospital
  1. Dr Hytinantti, Helsinki City Maternity Hospital, Sofianlehdonkatu 5, 00610 Helsinki, Finland
  • Accepted 22 October 1999

Abstract

AIM To study the relation between fetal growth and markers of collagen metabolism and insulin-like growth factor binding protein-1 (IGFBP-1) in term infants.

METHODS Cord vein plasma was obtained from 67 term infants of gestational age 37.1–41.7 weeks (39 appropriate for gestational age (AGA), 11 large for gestational age (LGA; relative birth weight ≥ 2.0 SD), and 17 small for gestational age (SGA; relative birth weight ≤ −2.0 SD)) for analysis of markers of metabolism of collagen type I (PICP and ICTP) and III (PIIINP) and of IGFBP-1.

RESULTS Negative correlations existed between gestational age and PICP (r = −0.294, p = 0.0158), ICTP (r = −0.338, p = 0.0052), and PIIINP (r = −0.432, p = 0.0003). These correlations were also found in SGA infants (all p < 0.05). IGFBP-1 showed negative correlations with birth weight and relative birth weight (r = −0.644, p = 0.0001, andr = −0.693, p = 0.0001 respectively) but not with gestational age (p>0.05).

CONCLUSIONS In the term fetus, collagen metabolism is primarily dependent on maturity and not on intrauterine growth status, whereas IGFBP-1 reflects intrauterine growth independently of maturity.

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