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Arch Dis Child Fetal Neonatal Ed 83:F135-F138 doi:10.1136/fn.83.2.F135
  • Original article

Developmental changes in erythrocyte Na+,K+-ATPase subunit abundance and enzyme activity in neonates

Table 2

Na+,K+-ATPase activity in purified erythrocyte membranes and the intracellular sodium ([Na+]ic) and potassium ([K+]ic) concentrations in the three groups

Group 1
(preterm neonates, 28–32 weeks)
Group 2
(preterm neonates, 33–36 weeks)
Group 3
(term neonates, 37–42 weeks)
Number of patients enrolled 56 58 122
Na+,K+-ATPase 624 (337)2-150 481 (195)2-151 404 (167)
(nmol ATP/h/mg protein) (n=37) (n=54) (n=113)
[Na+]ic (mmol/l) 7.09 (1.03) 7.22 (1.53) 8.04 (1.01)2-152
(n=24) (n=56) (n=17)
[K+]ic (mmol/l) 94.0 (13.3) 92.3 (11.0) 89.8 (15.5)
(n=16) (n=29) (n=18)
  • Values are means (SD).

  • 2-150 p < 0.05 v groups 2 and 3 (one factor analysis of variance; Fisher protected least squares difference test);

  • 2-151 p < 0.05 v group 3 (one factor analysis of variance; Fisher protected least squares difference test);

  • 2-152 p < 0.05 v groups 1 and 2 (one factor analysis of variance; Fisher protected least squares difference test); n = number of patients contributing to the given measurement. See the text for details.

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