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Arch Dis Child Fetal Neonatal Ed 2001;84:F40-F43 doi:10.1136/fn.84.1.F40
  • Original article

Study of maternal influences on fetal iron status at term using cord blood transferrin receptors

  1. D G Sweeta,
  2. G Savageb,
  3. T R J Tubmana,
  4. T R J Lappinb,
  5. H L Hallidaya
  1. aDepartment of Child Health, The Queen's University of Belfast and Regional Neonatal Unit, Royal Maternity Hospital, Belfast, UK, bDepartment of Haematology, The Queen's University of Belfast
  1. Dr D G Sweet, Perinatal Room, Royal Maternity Hospital, Grosvenor Road, Belfast BT12 6BB, Northern Ireland, UKdsweet{at}dnet.co.uk
  • Accepted 29 July 2000

Abstract

AIMS To determine effects of maternal iron depletion and smoking on iron status of term babies using serum transferrin receptors (STfR) and their ratio to ferritin (TfR-F index) in cord blood.

METHODS Iron, ferritin, STfR, and haemoglobin (Hb) concentration were measured and TfR-F index calculated in 67 cord /maternal blood pairs. Twenty six mothers were iron depleted (ferritin <10 μg/l) and 28 were smokers.

RESULTS Maternal iron depletion was associated with decreased cord ferritin (113v 171 μg/l) and Hb (156v 168 g/l) but no change in STfR or TfR-F index. Smoking was associated with increased cord Hb (168v 157 g/l) and TfR-F index (4.1v 3.4), and decreased ferritin (123v 190 μg/l). Cord TfR-F index and Hb were positively correlated (r = 0.48).

CONCLUSIONS Maternal iron depletion is associated with reduced fetal iron stores but no change in free iron availability. Smoking is associated with increased fetal iron requirements for erythropoiesis.

Footnotes

    Responses to this article

    • Translational regulation of TfR and ferritin - Authors' response
      • Henry L Halliday,
      • Terry RJ Lappin
      Arch Dis Child - Fetal Neonatal Ed published online March 24, 2001
    • Translational regulation of TfR and ferritin
      • Peter Reynolds
      Arch Dis Child - Fetal Neonatal Ed published online February 14, 2001
    • Newborns have unique confounding factors regarding the TfR-F ratio - Authors' response
      • Henry L Halliday
      Arch Dis Child - Fetal Neonatal Ed published online January 24, 2001
    • Newborns have unique confounding factors regarding the TfR-F ratio
      • Peter Reynolds
      Arch Dis Child - Fetal Neonatal Ed published online January 12, 2001

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