Effects of cisapride on QTc interval in term neonates
- Service de Pédiatrie 2, Centre Hospitalier Universitaire, 10 Bd Maréchal de Lattre de Tassigny, 21034 Dijon Cedex, France
- Dr Semama, Service de Pédiatrie 2, Hôpital d'Enfants, Centre Hospitalier Universitaire, 10 Bd Maréchal de Lattre de Tassigny, 21034 Dijon Cedex, Francedenis.semama{at}libertysurf.fr
- Accepted 29 August 2000
Abstract
BACKGROUND Cisapride administration for 48 hours has been shown to increase heart rate corrected QT (QTc) interval in preterm neonates. Accumulation of the drug because of liver enzyme immaturity has been suggested to be the reason. If this is correct, a longer survey of QTc interval should disclose an increase even in term neonates.
OBJECTIVE A prospective survey of the effects of cisapride on QTc interval in term neonates administered cisapride.
SETTING Neonatal Unit of the University Hospital of Dijon, France.
DESIGN QTc interval was determined just before and 48 hours, seven days, and 15 days after the start of treatment.
SUBJECTS Twenty one term newborn infants (mean gestational age 39.3 weeks) given the recommended dose of cisapride (0.2 mg/kg, four times a day).
RESULTS Administration of cisapride caused a significant increase in QTc interval (p < 0.01). The mean value increased from 0.397 before treatment to 0.418 after 48 hours, 0.431 by day 7, and 0.447 by day 15. A QTc interval exceeding 0.450 was found in six neonates: three at 48 hours, one at day 7, and two at day 15. In two infants, withdrawal of the drug was associated with normalisation of the QTc interval.
CONCLUSIONS These results support the hypothesis of cisapride accumulation in newborns due to enzymatic immaturity and indicate that QTc interval should be monitored in neonates receiving this drug.
