Neonatal paroxetine withdrawal syndrome
- aDivision of Neonatology, Morristown Memorial Hospital, Morristown, New Jersey, USA, bDivision of Clinical Pharmacology and Toxicology, Motherisk Program, Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
- Dr Itoito{at}sickkids.on.ca
- Accepted 31 October 2000
Abstract
Four term neonates presented with symptoms such as jitteriness and necrotising enterocolitis after paroxetine exposure in utero.
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Paroxetine withdrawal syndrome was suspected in four neonates exposed to the drug in utero at maternal doses ranging from 20 to 120 mg/day
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The symptoms and abnormalities included, but were not limited to, jitteriness, vomiting, irritability, hypoglycaemia, and necrotising enterocolitis
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Close observation is warranted for neonates exposed to paroxetine in utero
