Literature review (Medline) on recombinant tissue plasminogen activator (rt-PA) treatment in neonatal period
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Only data of reports with complete information were included. Requests for entire literature list of single cases tojhartmann{at}hdz-nrw.de. The bolus was a short infusion (10–60 minutes).
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3-150 Data collection was performed as a meta-analysis of all reports;
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3-151 up to four additional rt-PA infusions were given at intervals of 12–24 hours;
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3-152 only data of neonates were reviewed;
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3-153 bolus infusion was repeated twice with 0.1 mg/kg and twice with 0.2 mg/kg followed by continuous infusion of 0.06 mg/kg/h for 16 hours and 0.03 mg/kg/h for 18 hours;
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3-154 regimen was repeated after 12 hours;
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3-160 1.5 mg/kg once a day, 10% as bolus, 50% as infusion over one hour and 40% as infusion over two hours, repeated on six days;†† bolus dose was repeated 3 times.
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IVH, Intraventricular haemorrhage; NEC, necrotising enterocolitis.
