Neonatal alloimmune thrombocytopenia with significant HLA antibodies
- 1Department of Haematology, Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK
- 2Manchester Blood Centre, Plymouth Grove, Manchester, UK
- Correspondence to:
Dr Grainger, Department of Haematology, Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK;
jgrainger{at}bigfoot.com
- Accepted 29 November 2001
Abstract
A case of neonatal alloimmune thrombocytopenia (NAIT) secondary to human platelet antigen (HPA)-1a antibodies is reported. Additional multispecific HLA antibodies rendered volunteer donor platelet transfusions ineffective. Despite a high incidence of maternal HLA antibodies in the pregnant population, there is only one previous report of clinically significant HLA antibodies.
