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Arch Dis Child Fetal Neonatal Ed 2003;88:F6-F10 doi:10.1136/fn.88.1.F6
  • Review

Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn

  1. R Gottstein,
  2. R W I Cooke
  1. Neonatal Unit, Liverpool Women’s Hospital, Liverpool, UK
  1. Correspondence to:
    Dr Gottstein, Neonatal Unit, Liverpool Women’s Hospital, Crown Street, Liverpool L8 7SS, UK;
    rgottstein{at}btinternet.com
  • Accepted 23 April 2002

Abstract

Objectives: To assess the effectiveness of high dose intravenous immunoglobulin (HDIVIG) in reducing the need for exchange transfusion in neonates with proven haemolytic disease due to Rh and/or ABO incompatibility. To assess the effectiveness of HDIVIG in reducing the duration of phototherapy and hospital stay.

Design: Systematic review of randomised and quasi-randomised controlled trials comparing HDIVIG and phototherapy with phototherapy alone in neonates with Rh and/or ABO incompatibility.

Results: Significantly fewer infants required exchange transfusion in the HDIVIG group (relative risk (RR) 0.28 (95% confidence interval (CI) 0.17 to 0.47); number needed to treat 2.7 (95% CI 2.0 to 3.8)). Also hospital stay and duration of phototherapy were significantly reduced.

Conclusion: HDIVIG is an effective treatment.

Footnotes

    Responses to this article

    • Is Cochrane not in the archives?
      • T.H Koh
      Arch Dis Child - Fetal Neonatal Ed published online October 6, 2003
    • Reply to Ovaly and Cleary
      • R Gottstein,
      • RWI Cooke
      Arch Dis Child - Fetal Neonatal Ed published online June 27, 2003
    • Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn.
      • Andrew G Cleary,
      • Brian Brown, Jenny Minards, John Sills, Paula Bolton-Maggs
      Arch Dis Child - Fetal Neonatal Ed published online February 20, 2003
    • Late anemia in Rh hemolytic disease
      • Fahri Ovalý
      Arch Dis Child - Fetal Neonatal Ed published online February 6, 2003
    • High dose IVIG in hemolytic disease of neonates
      • Girish Gupta
      Arch Dis Child - Fetal Neonatal Ed published online January 28, 2003
    • IV immunoglobulin in haemolytic disaese of the newborn
      • Michael M Reid
      Arch Dis Child - Fetal Neonatal Ed published online January 7, 2003

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