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Arch Dis Child Fetal Neonatal Ed 88:F359-F364 doi:10.1136/fn.88.5.F359
  • Review

Neonatal thrombocytopenia: causes and management

Table 4

Guidelines for platelet transfusion in the newborn

Platelet count (× 109/l) Non-bleeding neonate Bleeding neonate NAITP (proven or suspected)
NAITP, Neonatal alloimmune thrombocytopenia; HPA, human platelet antigen; IVH, intraventricular haemorrhage; ET, endotracheal.
<30 Consider transfusion in all patients Transfuse Transfuse (with HPA compatible platelets)
30–49 Do not transfuse if clinically stable Transfuse Transfuse (with HPA compatible platelets if any bleeding)
Consider transfusion if:
  • <1000 g and <1 week of age

  • clinically unstable (e.g. fluctuating blood pressure or perfusion)

  • previous major bleeding (e.g. grade 3–4 IVH or pulmonary haemorrhage)

  • current minor bleeding (e.g. petechiae, puncture site oozing or blood stained ET secretions)

  • concurrent coagulopathy

  • requires surgery or exchange transfusion

50–99 Do not transfuse Transfuse Transfuse (with HPA compatible platelets if major bleeding present)
>99 Do not transfuse Do not transfuse Do not transfuse

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