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Arch Dis Child Fetal Neonatal Ed 89:F25-F28 doi:10.1136/fn.89.1.F25
  • Original article

Pharmacokinetics of single dose intravenous propacetamol in neonates: effect of gestational age

Table 3

Maturational trend (mean) of serum half life (t½) and relative distribution volume (relative Vd) in the first year of life after intravenous administration of propacetamol, based on this population* and on the study of Autret et al.10

Preterm (< 32 weeks)* Preterm (32–36 weeks)* Term (day 1)* Term (< 10 days) † < 1 year (10–365 days) †
Number infants 10 10 10 5 7
t½ (min) 290 265 172 210 126
Relative Vd (litre/kg) 0.66 0.56 0.61 0.7 0.9

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