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Arch Dis Child Fetal Neonatal Ed 89:F499-F503 doi:10.1136/adc.2002.023432
  • Original article

High dose caffeine citrate for extubation of preterm infants: a randomised controlled trial

Table 5

 Outcomes at 12 months corrected for prematurity

20 mg/kg (n = 87) 5 mg/kg (n = 86) RR (95% CI) p Value
Values are mean (SD) or number. Major disability defined as one or more of the following: cerebral palsy, bilateral blindness, need for hearing aids, GQ<75.
*Revised Griffiths developmental scale; †two infants for whom testing was not possible were excluded.
Developmental assessment n = 80 n = 78
    General quotient (GQ)* 96.6 (13.2) 92.2 (17.3)† 0.08
    Major disability 6 14 0.42 (0.17 to 1.05) 0.05
    Death up to 12 months of age 7 8
    Death or disability 13 22 0.58 (0.32 to 1.08) 0.08

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