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Arch Dis Child Fetal Neonatal Ed 2004;89:F551-F554 doi:10.1136/adc.2003.030049
  • Original article

Lipopolysaccharide binding protein in preterm infants

  1. D Behrendt,
  2. J Dembinski,
  3. A Heep,
  4. P Bartmann
  1. Department of Neonatology, University Children’s Hospital, University of Bonn, D-53113 Bonn, Germany
  1. Correspondence to:
    Dr Behrendt
    Department of Neonatology, University Children’s Hospital, University of Bonn, D-53113 Bonn, Germany; danibehrendt01019freenet.de
  • Accepted 22 October 2003

Abstract

Objective: To assess serum concentrations of lipopolysaccharide binding protein (LBP) in preterm infants with neonatal bacterial infection (NBI).

Methods: Blood samples were analysed of 57 preterm (28+1 to 36+6, median 33+2 weeks gestation) and 17 term infants admitted to the neonatal intensive care unit within the first 72 hours of life with suspicion of NBI. Samples were obtained at first suspicion of sepsis and after 12 and 24 hours. Diagnosis of NBI was confirmed by raised concentrations of C reactive protein and/or interleukin 6. The influence of gestational age and labour was analysed.

Results: Maximum LBP concentrations in infants with NBI were greatly increased compared with infants without NBI (13.0–46.0 μg/ml (median 20.0 μg/ml) v 0.6–17.4 μg/ml (median 4.2 μg/ml)). LBP concentrations in infected infants were not yet significantly raised when NBI was first suspected. The LBP concentrations of preterm infants were comparable to those of term infants. Regression analysis revealed no significant effect of labour or gestational age on LBP.

Conclusions: Raised LBP concentrations indicate NBI in preterm and term infants. Preterm infants of > 28 weeks gestation seem to be capable of producing LBP as efficiently as term infants. Neonatal LBP concentrations are not influenced by labour. LBP may be a useful diagnostic marker of NBI in preterm infants.

Footnotes

    Responses to this article

    • Reply to Thayyil et al. concerning "Lipopolysaccharide binding protein in preterm infants"
      • Daniela C Behrendt,
      • Jörg Dembinski, Axel Heep, Peter Bartmann
      Arch Dis Child - Fetal Neonatal Ed published online March 21, 2005
    • Lipopolysaccharide binding protein in preterm infants
      • Sudhin Thayyil,
      • Anna Curley and Nicholas Brown
      Arch Dis Child - Fetal Neonatal Ed published online December 21, 2004

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