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Arch Dis Child Fetal Neonatal Ed 2004;89:F558-F559 doi:10.1136/adc.2003.034017
  • Short report

Testosterone measurements in early infancy

  1. C Tomlinson1,
  2. H Macintyre2,
  3. C A Dorrian2,
  4. S F Ahmed1,
  5. A M Wallace2
  1. 1Bone & Endocrine Research Group, Department of Child Health, Royal Hospital For Sick Children, Yorkhill, Glasgow G3 8SJ, Scotland, UK
  2. 2Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow G4 0SF
  1. Correspondence to:
    Dr Wallace
    Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow G4 0SF, Scotland, UK; MWallacegri-biochem.org.uk
  • Accepted 5 March 2004

Abstract

Circulating testosterone concentrations in infants measured by a direct chemiluminescent immunoassay (Bayer ADVIA Centaur) were compared with those measured by a traditional radioimmunoassay using solvent extraction. The results confirm that neonatal circulating testosterone concentrations are method dependent, and each laboratory should establish method related reference ranges especially if using a direct commercial immunoassay. The results indicate that the Bayer ADVIA Centaur procedure can be used reliably in neonates. Expected values for male and female infants < 10 days old were 2.5–11.1 (n  =  36) and 1.7–5.6 (n  =  36) nmol/l respectively. For older neonates (10–50 days) the ranges were 0.2–17.2 (n  =  42) and 0.1–1.5 (n  =  7) nmol/l respectively.

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